abstract：:Recent studies suggest differential roles for CD103+ and CD11bhi lung dendritic cells (LDCs) in host defense against viral and bacterial infections. In this study, we examined the contribution of these LDC subsets in protective immunity to chlamydial lung infection using a Chlamydia muridarum mouse infection model. We...

journal_title：Cellular & molecular immunology

authors： Shekhar S,Peng Y,Wang S,Yang X

更新日期：2018-04-01 00:00:00

abstract：:Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited disorders, suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation. Although present in high counts, neutrophils fail to clear infection in the airways. High levels ...

journal_title：Cellular & molecular immunology

authors： Cockx M,Gouwy M,Van Damme J,Struyf S

更新日期：2018-04-01 00:00:00

abstract：:The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an important role in the pathogenesis of many autoimmune diseases. However, the role of CD24 in T-cell-mediated liver...

journal_title：Cellular & molecular immunology

authors： Zheng C,Yin S,Yang Y,Yu Y,Xie X

更新日期：2018-03-01 00:00:00

abstract：:The outcome of hepatitis B viral (HBV) infection is determined by the complex interactions between replicating HBV and the immune system. While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively, the contribution of innate immune mechanisms remains to be defined. Her...

journal_title：Cellular & molecular immunology

authors： Ma Z,Liu J,Wu W,Zhang E,Zhang X,Li Q,Zelinskyy G,Buer J,Dittmer U,Kirschning CJ,Lu M

更新日期：2017-12-01 00:00:00

abstract：:4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism. We found that treatment with agonistic anti-4-1BB mAb promoted ...

journal_title：Cellular & molecular immunology

authors： Choi BK,Lee DY,Lee DG,Kim YH,Kim SH,Oh HS,Han C,Kwon BS

更新日期：2017-09-01 00:00:00

abstract：:Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial ...

journal_title：Cellular & molecular immunology

authors： Kearney CJ,Randall KL,Oliaro J

更新日期：2017-05-01 00:00:00

abstract：:Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Altho...

journal_title：Cellular & molecular immunology

authors： Zhang J,Dunk CE,Kwan M,Jones RL,Harris LK,Keating S,Lye SJ

更新日期：2017-02-01 00:00:00

abstract：:Neonates are at increased risk of viral encephalopathies that can result in neurological dysfunction, seizures, permanent disability and even death. The neurological damage results from the combined effect of the virus and the immune response it elicits, thus finding tools to facilitate viral clearance from central ne...

journal_title：Cellular & molecular immunology

authors： Ireland DD,Tami C,Pedras-Vasconcelos J,Verthelyi D

更新日期：2017-01-01 00:00:00

abstract：:Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However...

journal_title：Cellular & molecular immunology

authors： Ratsimandresy RA,Indramohan M,Dorfleutner A,Stehlik C

更新日期：2017-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B-cell hyperreactivity. The Toll-like receptor 7 (TLR7) signaling pathway is abnormally activated in SLE B cells. CyclinD3 (CCND3) plays an important role in B-cell proliferation, development, and differentiation. Although previous studies fo...

journal_title：Cellular & molecular immunology

authors： Ren D,Liu F,Dong G,You M,Ji J,Huang Y,Hou Y,Fan H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Plasma phospholipid transfer protein (PLTP) is a key determinant of lipoprotein metabolism, and both animal and human studies converge to indicate that PLTP promotes atherogenesis and its thromboembolic complications. Moreover, it has recently been reported that PLTP modulates inflammation and immune response...

journal_title：Cellular & molecular immunology

authors： Desrumaux C,Lemaire-Ewing S,Ogier N,Yessoufou A,Hammann A,Sequeira-Le Grand A,Deckert V,Pais de Barros JP,Le Guern N,Guy J,Khan NA,Lagrost L

更新日期：2016-11-01 00:00:00

abstract：:We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein (rLrp) inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription fact...

journal_title：Cellular & molecular immunology

authors： Liu Y,Li JY,Chen ST,Huang HR,Cai H

更新日期：2016-11-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer (CAC) models induced using both dextran sulfate sodium (DSS) and the azoxymethane/DSS protocol were established in wild-type (WT) and CTRP4 transgenic...

journal_title：Cellular & molecular immunology

authors： Luo Y,Wu X,Ma Z,Tan W,Wang L,Na D,Zhang G,Yin A,Huang H,Xia D,Zhang Y,Shi X,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...

journal_title：Cellular & molecular immunology

authors： Liu GY,Liu Y,Lu Y,Qin YR,Di GH,Lei YH,Liu HX,Li YQ,Wu C,Hu XW,Duan HF

更新日期：2016-05-01 00:00:00

abstract：:Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NL...

journal_title：Cellular & molecular immunology

authors： Jo EK,Kim JK,Shin DM,Sasakawa C

更新日期：2016-03-01 00:00:00

abstract：:While there is mounting evidence that interleukin (IL)-23-IL-17 axis plays a critical role in the pathogenesis of various autoimmune diseases, much remains to be elucidated on how IL-23 is induced in the pathological processes. IL-23 is a heterodimer composed of p19 and p40, the latter being shared with IL-12. We prev...

journal_title：Cellular & molecular immunology

authors： Ma X,Aoki T,Narumiya S

更新日期：2016-03-01 00:00:00

abstract：:Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol feeding synergistically induces hepatic recruitment of neutrophils, which contributes to liver injury. In this paper, we investigated the roles o...

journal_title：Cellular & molecular immunology

authors： Mathews S,Feng D,Maricic I,Ju C,Kumar V,Gao B

更新日期：2016-03-01 00:00:00

abstract：:Potential crosslinks between inflammation and leukaemia have been discussed for some time, but experimental evidence to support this dogma is scarce. In particular, it is important to understand the mechanisms responsible for potential upregulation of proto-oncogenic growth factor expressions by inflammatory mediators...

journal_title：Cellular & molecular immunology

authors： Wyszynski RW,Gibbs BF,Varani L,Iannotta D,Sumbayev VV

更新日期：2016-01-01 00:00:00

abstract：:The disruption of epithelial barrier integrity is an important factor in the pathogenesis of various immune disorders. However, the restitution of the compromised barrier functions is difficult. This study investigates the regulation of TWIK-related potassium channel-1 (Trek1) in the restitution of intestinal epitheli...

journal_title：Cellular & molecular immunology

authors： Huang H,Liu JQ,Yu Y,Mo LH,Ge RT,Zhang HP,Liu ZG,Zheng PY,Yang PC

更新日期：2016-01-01 00:00:00

abstract：:Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We aimed to assess the effects of simulated weightlessness (Second Berlin BedRest Study; BBR2-2) on immunologica...

journal_title：Cellular & molecular immunology

authors： Hoff P,Belavý DL,Huscher D,Lang A,Hahne M,Kuhlmey AK,Maschmeyer P,Armbrecht G,Fitzner R,Perschel FH,Gaber T,Burmester GR,Straub RH,Felsenberg D,Buttgereit F

更新日期：2015-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expressio...

journal_title：Cellular & molecular immunology

authors： Neve Polimeno M,Ierano C,D'Alterio C,Simona Losito N,Napolitano M,Portella L,Scognamiglio G,Tatangelo F,Maria Trotta A,Curley S,Costantini S,Liuzzi R,Izzo F,Scala S

更新日期：2015-07-01 00:00:00

abstract：:B cells play an important role in the clearance of hepatitis B virus (HBV) and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of p...

journal_title：Cellular & molecular immunology

authors： Xu X,Shang Q,Chen X,Nie W,Zou Z,Huang A,Meng M,Jin L,Xu R,Zhang JY,Fu J,Wang L,Tang Z,Xie Y,Yang X,Zhang Z,Wang FS

更新日期：2015-05-01 00:00:00

abstract：:Some pathogens can use host suppressor of cytokine signaling 1 (SOCS-1), an important negative-feedback molecule, as the main mode of immune evasion. Here we found that group A Streptococcus (GAS) is capable of inducing SOCS-1 expression in RAW264.7 and BMDM macrophages. IFN-β plays a role in GAS-induced SOCS-1 expres...

journal_title：Cellular & molecular immunology

authors： Wu J,Ma C,Wang H,Wu S,Xue G,Shi X,Song Z,Wei L

更新日期：2015-05-01 00:00:00

abstract：:Cytomegaloviruses (CMVs), members of the herpesvirus family, have evolved a variety of mechanisms to evade the immune response to survive in infected hosts and to establish latent infection. They effectively hide infected cells from the effector mechanisms of adaptive immunity by eliminating cellular proteins (major h...

journal_title：Cellular & molecular immunology

authors： Lučin P,Mahmutefendić H,Blagojević Zagorac G,Ilić Tomaš M

更新日期：2015-03-01 00:00:00

abstract：:It has recently been established that neutrophils, the most abundant leukocytes, are capable of changes in gene expression during inflammatory responses. However, changes in the transcriptome as the neutrophil leaves the bone marrow have yet to be described. We hypothesized that neutrophils are transcriptionally activ...

journal_title：Cellular & molecular immunology

authors： Lakschevitz FS,Visser MB,Sun C,Glogauer M

更新日期：2015-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs, and changes in miRNAs are involved in tumor origin and progression. Studies have shown that miR-20a is overexpressed in human ovarian cancer tissues and that this miRNA enhances long-term cellular proliferation and invasion capabilities. In this study...

journal_title：Cellular & molecular immunology

authors： Xie J,Liu M,Li Y,Nie Y,Mi Q,Zhao S

更新日期：2014-09-01 00:00:00

abstract：:The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...

journal_title：Cellular & molecular immunology

authors： Rajagopalan S

更新日期：2014-09-01 00:00:00

abstract：:Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14...

journal_title：Cellular & molecular immunology

authors： Zheng J,Liang H,Xu C,Xu Q,Zhang T,Shen T,Lu F

更新日期：2014-05-01 00:00:00

abstract：:Immunoglobulins (Igs) are known to be synthesized and secreted only by B lymphocytes. Class switch recombination (CSR) is a key event that enables B cells to express Igs, and one of the crucial steps for CSR initiation is the germline transcription of Ig genes. Surprisingly, recent studies have demonstrated that the I...

journal_title：Cellular & molecular immunology

authors： Duan Z,Zheng H,Xu S,Jiang Y,Liu H,Li M,Hu D,Li W,Bode AM,Dong Z,Cao Y

更新日期：2014-03-01 00:00:00

abstract：:The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design of more efficient protocols for cancer chemoimmunotherapy. It is well known that danger-associated mol...

journal_title：Cellular & molecular immunology

authors： Fang H,Ang B,Xu X,Huang X,Wu Y,Sun Y,Wang W,Li N,Cao X,Wan T

更新日期：2014-03-01 00:00:00

abstract：:Previously, we demonstrated that macrophages from thrombospondin 1 (TSP1)-deficient mice have a reduced inflammatory phenotype, suggesting that TSP1 plays a role in macrophage activation. In this study, we determined how TSP1 regulates macrophage function. We found that recombinant or purified platelet human TSP1 trea...

journal_title：Cellular & molecular immunology

authors： Li Y,Qi X,Tong X,Wang S

更新日期：2013-11-01 00:00:00

abstract：:Apoptotic cell transfer has been found to be able to facilitate engraftment of allograft. However, the underlying mechanisms remain to be fully understood. Here we demonstrate that intravenous administration of donor apoptotic splenocytes can promote pancreatic islet engraftment by inducing generation of tolerogenic d...

journal_title：Cellular & molecular immunology

authors： Wu C,Zhang Y,Jiang Y,Wang Q,Long Y,Wang C,Cao X,Chen G

更新日期：2013-09-01 00:00:00

abstract：:B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4(+) T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions...

journal_title：Cellular & molecular immunology

authors： Yang M,Rui K,Wang S,Lu L

更新日期：2013-03-01 00:00:00

abstract：:Vγ2Vδ2 T (also known as Vγ9Vδ2 T) cells exist only in primates, and in humans represent a major γδ T-cell sub-population in the total population of circulating γδ T cells. Results from recent studies suggest that while (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen from Mycobacterium tuberculos...

journal_title：Cellular & molecular immunology

authors： Chen ZW

更新日期：2013-01-01 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) disrupts the balance among γδ T cell subsets, with increasing Vδ1+ cells and substantial depletion of circulating Vδ2+ cells. Depletion is an indirect effect of HIV in CD4-negative Vδ2 cells, but is specific for phosphoantigen-responsive subpopulations identified by th...

journal_title：Cellular & molecular immunology

authors： Li H,Chaudhry S,Poonia B,Shao Y,Pauza CD

更新日期：2013-01-01 00:00:00

abstract：:T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching ...

journal_title：Cellular & molecular immunology

authors： Kemeny DM

更新日期：2012-09-01 00:00:00

abstract：:Trogocytosis is a process which involves the transfer of membrane fragments and cell surface proteins between cells. Various types of T cells have been shown to be able to acquire membrane-bound proteins from antigen-presenting cells and their functions can be modulated following trogocytosis. However, it is not known...

journal_title：Cellular & molecular immunology

authors： Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L

更新日期：2012-03-01 00:00:00

abstract：:Complications arising from abnormal immune responses are the major causes of mortality and morbidity in diabetic patients. CD4+CD25+T regulatory cells (Tregs) play pivotal roles in controlling immune homeostasis, immunity and tolerance. The effect of hyperglycemia on CD4+CD25+Tregs has not yet been addressed. Here we ...

journal_title：Cellular & molecular immunology

authors： Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y

更新日期：2012-01-01 00:00:00

abstract：:Intestinal stem cells may have important roles in the maintenance of epithelial integrity during tissue repair. Alemtuzumab is a humanized anti-CD52 lymphocytic antibody that is increasingly being used to induce immunosuppression; intestinal barrier function is impaired during treatment with alemtuzumab. We investigat...

journal_title：Cellular & molecular immunology

authors： Li Q,Zhang Q,Wang C,Jiang S,Li N,Li J

更新日期：2011-07-01 00:00:00

abstract：:The major limitation for the maturation of dendritic cells (DCs) using Toll-like receptor (TLR) agonists is their decreased ability to migrate into lymph nodes compared with conventional DCs. CD38 can be used as a multifunctional marker to modulate migration, survival and Th1 responses of DCs. CD74 has been shown to n...

journal_title：Cellular & molecular immunology

authors： Nguyen-Pham TN,Lim MS,Nguyen TA,Lee YK,Jin CJ,Lee HJ,Hong CY,Ahn JS,Yang DH,Kim YK,Chung IJ,Park BC,Kim HJ,Lee JJ

更新日期：2011-07-01 00:00:00